A Top-Down Approach to Network Modelling in Systems Biology
Trey Ideker has recently presented an interesting overview of the various strategies his group at the NIH Systems Biology Special Interest Group has been developing in the recent years in order to integrate multiple types of large scale datasets. During his talk he has gone through these points:
- mapping of transcriptional response pathways
- functional mapping of protein complexes
- disease diagnosis and stratification
Trey presented the study recently published in Molecular Systems Biology (Chuang et al, 2007) where the information provided by microarray expression profiling is superposed to a protein-protein physical interaction network to identify ‘subnetwork’ biomarkers that classify metastatic vs non-metastatic breast tumors.
From: the seven stonesBioinformatics, Synthetic Biology